More than 300 racers ran on Gay Street on Saturday morning.
It's part of the 6K fun run and 2K walk to benefit the East Tennessee Kidney Foundation.
Runners raced through Downtown Knoxville to raise money for low income patients who have kidney disease.
Officials say the money will help provide transportation for those patients who can't afford to get to their dialysis treatments.
"It's just very important because people with kidney disease have to get their dialysis treatments or they'll pass away. So people that can't afford it... just the more money we can raise, the more people we can help get to dialysis so that they can have a longer and better life-- hopefully get that kidney transplant that they need," said Katie Caldwell, executive director of the East Tennessee Kidney Foundation.
Organizers said they raised thousands of dollars with the race.